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Real-world adherence to injectable GLP-1 therapy has been disappointing: data from pharmacy claims analyses show that approximately 50-70% of patients discontinue GLP-1R agonists within the first year, with cost, side effects, and injection burden cited as the primary reasons

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In Laron dwarfism, due to the insensitivity to GH, and in GHR knock-out mice, appropriate testicular function develops later than in healthy males, but still occurred (88)